Cell Lines and Cell Cultures
Biochain Institute Inc Frozen Tissue Section - Progressive Supranuclear Palsy: Brain: Cerebellum, 5 slides/PK
BioChain's tissue products are based on the sample repository network established following the IRB-approved ethical standard and procedures. BioChain's Frozen Tissue Slides are ideal for rapidly identifying cellular localization of RNA or protein. A single human adult normal tissue with 5-10 um thickness is mounted on a positively charged glass slide. The slides are fixed and dehydrated with acetone for consistent results with in situ hybridization and immunohistochemistry. More organs may be available upon request.
Eurofins Discoverx PathHunter U2OS TGFBR1/TGFBR2 Dimerization Cell Line, 2 vials. (93-0889C3)
The PathHunter TGFBR1/TGFBR2 Dimerization cell line is a stable, engineered cell line for use in studying drug candidates (small molecules or biologics) targeting receptor-receptor interaction. This cell line enables assessment of ligand (e.g. TGF-β1) induced dimerization of TGFBR1/TGFBR2 receptors. This product uses EFC technology. The cell line included overexpresses TGFBR1 target protein fused to PK alongside TGFBR2 target protein fused to EA. Upon ligand-induced dimerization of TGFBR1/TGFBR2, detectable EFC signal is produced. This stable modified cell line is provided as two vials of cryopreserved cells. For detailed product information, User Manual and datasheet, visit www.discoverx.com/kinases.
Electron Microscopy Sciences Rodent Brain Matrix Guinea Pig, 250-450g, Coronal
RBM allow the investigator to slice either coronal (perpendicular to center line) or sagittal (parallel to center line) sections through the brain at intervals as small as 1mm. All RBM's are identical and durable to insure reproducible sections in the day-to-day, year-to-year, or on a between laboratory basis.
Constructed from high grade zinc to allow for rapid temperature equilibration, easy cleaning, and sterilization. The matrices are designed to accommodate the brains of rodents placed ventral side up. The channels are precisely cut at 1 mm intervals and 0.3 mm wide.
Size: 250-450g
Type: Coronal
Eurofins Discoverx ChemiScreen M2 Muscarinic Acetylcholine Receptor Stable Cell Line, 2 vials. (HTS115C)
The ChemiScreen M2 Muscarinic Acetylcholine Receptor Stable Cell Line is an engineered cell line for use in studying drug candidates (small molecules or biologics) targeting GPCRs. This cell line enables assessment of ligand (e.g. acetylcholine) based activation of CHRM2 GPCR activity via detection of increasing levels of intracellular calcium. The included cell line overexpresses CHRM2 alongside endogenous high levels of the promiscuous G protein, Gα15, coupling the receptor to the calcium signaling pathway. Upon activation of CHRM2, the resulting calcium activity can be fluorescently assayed. This stable modified cell line is provided as two vials of cryopreserved cells. For detailed product information, visit www.discoverx.com/targets/gpcr-target-biology.
Eurofins Discoverx ChemiBrite EP2 Prostanoid Receptor Stable Cell Line, 2 vials. (HTS185L)
The ChemiBrite EP2 Prostanoid Receptor cell line is a stable, engineered cell line for use in studying drug candidates (small molecules or biologics) targeting GPCRs. This cell line enables assessment of ligand (e.g. prostaglandin E2) based activation of PTGER2 GPCR activity via detection of increasing levels of intracellular calcium. The included cell line overexpresses PTGER2 alongside exogenous high levels of a promiscuous G-protein, coupling the receptor to the calcium signaling pathway. ChemiBrite cells also express a clytin variant, allowing for luminescent as well as fluorescent signal detection. Upon activation of PTGER2, the resulting calcium activity can be assayed in either detection mode. This stable modified cell line is provided as two vials of cryopreserved cells. For detailed product information, visit www.discoverx.com/targets/gpcr-target-biology.
ATCC Helicobacter pylori
Helicobacter pylori strain NCTC 11637 is a whole-genome sequenced bacterial type strain that was isolated from the human gastric antrum. This strain can be used in enteric research or as a quality control strain.
ATCC Lactobacillus acidophilus; genomic DNA
Genomic DNA isolated from Lactobacillus acidophilus Strain Pak. This bacterial strain is also available as ATCC® Catalog No. 4357™.
Biochain Institute Inc Paraffin Tissue Section - Human Adult Normal: Brain: Cerebellum (left), 5 slides/PK
BioChain's tissue products are based on the sample repository network established following the IRB-approved ethical standard and procedures. BioChain's formalin fixed paraffin embedded (FFPE) tissue section line encompasses a large selection of tissue sections which are suitable for immunohistochemistry and in situ hybridization assays. The tissue sections are approximately 5 um thick. For those customers who want to perform FFPE DNA and RNA isolation, BioChain can provide tissue section slices in tubes instead of mounting them on glass slides.
Eurofins Discoverx PathHunter CHO-K1 GALR2 β-Arrestin Cell Line, 2 vials. (93-0759C2)
The PathHunter GALR2 cell line is a stable, engineered cell line for use in studying drug candidates (small molecules or biologics) targeting GPCRs. This cell line enables assessment of ligand (e.g. galanin) based activation of GALR2 GPCR activity via detection of β-arrestin recruitment. The included cell line overexpresses ProLink-tagged GALR2 and EA-tagged β-Arrestin-2. Activation of GALR2 stimulates the recruitment of β-Arrestin-2 and produces EFC signal. This stable modified cell line is provided as two vials of cryopreserved cells. For detailed product information, User Manual and datasheet, visit www.discoverx.com/gpcr.